NS9283 | α4β2 nAChR PAM | Probechem Biochemicals

Chemical Structure : NS9283

CAS No.: 913830-15-6

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NS9283 (NS 9283, NS-9283)

货号: PC-21601Not For Human Use, Lab Use Only.

NS9283 is a potent, positive allosteric modulator of α4β2 nAChR, acts selectively at 3α:2β stoichiometry of α2* and α4* nAChRs.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
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100 mg		Get quote

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生物&药学活性

NS9283 is a potent, positive allosteric modulator of α4β2 nAChR, acts selectively at 3α:2β stoichiometry of α2* and α4* nAChRs.
NS9283 selectively increases ACh potency at the 3α:2β receptors while it does not modulate current conducted by the 2α:3β receptors.
NS9283 was demonstrated to increase the potency of ACh-evoked currents in HEK293-hα4β2 cells by left-shifting the concentration–response curve ∼60-fold.
NS9283 has favourable effects on sensory information processing, as shown by reversal of PCP-disrupted pre-pulse inhibition.
NS9283 improved performance in a rat model of episodic memory (social recognition), a rat model of sustained attention.

物理化学性质&存储条件

分子量	248.25
分子式	C14H8N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[3-(3-pyridyl)-1,2,4-oxadiazol-5-yl] benzonitrile

参考文献

1. Timmermann DB, et al. Br J Pharmacol. 2012 Sep;167(1):164-82.

2. Grupe M, et al. Br J Pharmacol. 2013 Apr;168(8):2000-10.

NS9283 (NS 9283, NS-9283)

生物&药学活性

物理化学性质&存储条件

参考文献

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NS9283 (NS 9283, NS-9283)

生物&药学活性

物理化学性质&存储条件

参考文献

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