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首页-小分子抑制剂&激动剂-Others-Other Targets-NS5806
NS5806

Chemical Structure : NS5806

CAS No.:

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NS5806 (NS 5806)

货号: PC-20595Not For Human Use, Lab Use Only.

NS5806 is a small molecule cardiac troponin (cTnC) activator, binds to Ca2+-saturated cChimera with Kd of 7.6 uM, stabilizes active troponin, significantly increases the ATPase activity of cardiac myofibrils in a dose-dependent manner.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NS5806 is a small molecule cardiac troponin (cTnC) activator, binds to Ca2+-saturated cChimera with Kd of 7.6 uM, stabilizes active troponin, significantly increases the ATPase activity of cardiac myofibrils in a dose-dependent manner.
NS5806 occupies a binding pocket formed by both the Ca2+-saturated NcTnC and cTnISP.
NS5806 strongly increases the calcium sensitivity of force development of demembranated human muscle strips as indicated by an increase in pCa50 by about 0.2 pCa.
NS5806 is a novel calcium sensitizer that stabilizes active troponin.

物理化学性质&存储条件

分子量 572.10
分子式 C18H10Br2F6N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(CC1=C(C2=NNN=N2)C=C(Br)C=C1Br)CC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3

参考文献

1. Priyanka Parijat, et al. Sci Rep. 2023 Mar 30;13(1):5216.

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