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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Chloride Channel-NS3728
NS3728

Chemical Structure : NS3728

CAS No.: 265646-85-3

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NS3728 (Emidurdar, Endovion, SCO-101, SCO101)

货号: PC-38096Not For Human Use, Lab Use Only.

NS3728 (Emidurdar, SCO-101) is a potent volume-regulated anion channel (VRAC) blocker with IC50 of 460 nM.

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10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3680 In stock
100 mg ￥5680 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NS3728 (Emidurdar, SCO-101) is a potent volume-regulated anion channel (VRAC) blocker with IC50 of 460 nM.
NS3728 blocks red blood cell chloride conductance (IC50 = 0.6 μM).
NS 3728 also inhibits Ca2+-activated Cl- current (CaCC) by anoctamin (ANO) in an apparently voltage-dependent manner (IC50 against ANO1 = 2.1 and 0.7 μM at -95 and +50 mV, respectively).

物理化学性质&存储条件

分子量 495.18
分子式 C16H9BrF6N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)urea

参考文献

1. Klausen TK, et al. J Cell Physiol. 2007 Mar;210(3):831-42.

2. Schneider L, et al. Pflugers Arch. 2008 Mar;455(6):1055-62.

3. Kjaer K, et al. Brain Res. 2009 Jul 24;1281:15-24.

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