NS3623 |CAS:343630-41-1 Probechem Biochemicals

Chemical Structure : NS3623

CAS No.: 343630-41-1

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NS3623 (NS-3623;NS 3623)

货号: PC-60833Not For Human Use, Lab Use Only.

NS3623 is a novel human RBC Cl-conductance blocker (IC50=210 nM) and HERG channel activitor (EC50=79.4 uM, HERG1 channel activation).

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5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2380	In stock
50 mg	￥3880	In stock
100 mg		Get quote

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生物&药学活性

NS3623 is a novel human RBC Cl-conductance blocker (IC50=210 nM) and HERG channel activitor (EC50=79.4 uM, HERG1 channel activation).
NS-3623 inhibits RBC g(Cl) after oral administration to normal mice (ED50= 25 mg/kg), ameliorates erythrocyte dehydration in transgenic SAD mice.
NS-3623 increases the macroscopic current conducted by the hERG channels by increasing the time constant for channel inactivation.
NS-3623 affects native I(Kr), decreases QT variability and distinctly decreases the occurrence of extrasystoles in the acutely bradypaced hearts.

物理化学性质&存储条件

分子量	427.185
分子式	C15H10BrF3N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea

参考文献

1. Bennekou P, et al. Blood. 2001 Mar 1;97(5):1451-7.

2. Hansen RS, et al. Mol Pharmacol. 2006 Oct;70(4):1319-29.

3. Hansen RS, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):996-1002.

4. Hansen RS, et al. J Cardiovasc Pharmacol. 2008 Jul;52(1):35-41.

NS3623 (NS-3623;NS 3623)

生物&药学活性

物理化学性质&存储条件

参考文献

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NS3623 (NS-3623;NS 3623)

生物&药学活性

物理化学性质&存储条件

参考文献

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