NS19504 |CAS:327062-46-4 Probechem Biochemicals

Chemical Structure : NS19504

CAS No.: 327062-46-4

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NS19504 (NS-19504;NS 19504)

货号: PC-60653Not For Human Use, Lab Use Only.

A novel selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM.

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10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
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生物&药学活性

NS19504 is a selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM.
NS19504 shows a favorable selectivity profile on Nav, Cav, SK, and IK channels.
NS19504 causes distinct activation from a concentration of 0.3 and 10 µM NS19504 left-shifted the voltage activation curve by 60 mV.
NS19504 reduces spontaneous phasic contractions in guinea pig urinary bladder strips at 1 uM, while having only a modest effect on contractions evoked by electrical field stimulation (EFS) and no effect on high K+-induced contractions.

物理化学性质&存储条件

分子量	269.16
分子式	C10H9BrN2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in DMSO
Chemical Name/SMILES	5-[(4-bromophenyl)methyl]-1,3-thiazol-2-amine

参考文献

1. Nausch B, et al. J Pharmacol Exp Ther. 2014 Sep;350(3):520-30.

NS19504 (NS-19504;NS 19504)

生物&药学活性

物理化学性质&存储条件

参考文献

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NS19504 (NS-19504;NS 19504)

生物&药学活性

物理化学性质&存储条件

参考文献

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