NS15370 |CAS:2729996-51-2 Probechem Biochemicals

首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-NS15370

Chemical Structure : NS15370

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NS15370 (NS-15370;NS 15370)

货号: PC-60229Not For Human Use, Lab Use Only.

NS15370 is a highly potent positive modulator of Kv7 channels with EC50 of 100 nM (Kv7.2-Kv7.5).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NS15370 is a highly potent positive modulator of Kv7 channels with EC50 of 100 nM (Kv7.2-Kv7.5).
NS15370 hyperpolarizes and increases spike frequency adaptation of hippocampal CA1 neurons in brain slices.
NS15370 reduces MK-801-induced hyperactivity in models of partial epilepsia.

物理化学性质&存储条件

分子量	442.442
分子式	C23H21F3N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3,5-difluorophenyl)-N-(6-((4-fluorophenyl)amino)-2-morpholinopyridin-3-yl)acetamide

参考文献

1. Dalby-Brown W, et al. Eur J Pharmacol. 2013 Jun 5;709(1-3):52-63.

2. Jepps TA, et al. Br J Pharmacol. 2014 Oct;171(19):4413-24.

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NS15370 (NS-15370;NS 15370)

生物&药学活性

物理化学性质&存储条件

参考文献

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NS15370 (NS-15370;NS 15370)

生物&药学活性

物理化学性质&存储条件

参考文献

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