NS13001 |CAS:1062592-30-6 Probechem Biochemicals

Chemical Structure : NS13001

CAS No.: 1062592-30-6

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NS13001 (NS 13001;NS-13001)

货号: PC-60782Not For Human Use, Lab Use Only.

NS13001 is a potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively.

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10 mg	￥1680	In stock
25 mg	￥2880	In stock
50 mg	￥4980	In stock
100 mg		Get quote

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生物&药学活性

NS13001 is a potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively.
NS13001 shows no activating effect on hSK1 or hIK channels (EC50>10 uM), and exerts less off-target effects.
NS13001 alleviates behavioral and neuropathological phenotypes of aging spinocerebellar ataxia type 2 (SCA2) transgenic mice.

物理化学性质&存储条件

分子量	339.787
分子式	C16H14ClN7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-chlorophenyl)-9-methyl-2-(3-methyl-1H-pyrazol-1-yl)-9H-purin-6-amine

参考文献

1. Kasumu AW, et al. Chem Biol. 2012 Oct 26;19(10):1340-53.

2. Coleman N, et al. Mol Pharmacol. 2014 Sep;86(3):342-57.

NS13001 (NS 13001;NS-13001)

生物&药学活性

物理化学性质&存储条件

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NS13001 (NS 13001;NS-13001)

生物&药学活性

物理化学性质&存储条件

参考文献

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