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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-NS 11021
NS 11021

Chemical Structure : NS 11021

CAS No.: 956014-19-0

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NS 11021 (NS11021)

货号: PC-73206Not For Human Use, Lab Use Only.

NS11021 is a potent and specific activator of large-conductance Ca2+-activated potassium channels (BKCa/KCa1.1).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NS11021 is a potent and specific activator of large-conductance Ca2+-activated potassium channels (BKCa/KCa1.1).
NS11021 activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials at >0.3 uM.
NS11021 increased the open probability of the channel by altering gating kinetics without affecting the single-channel conductance.
NS11021 influenced neither a number of cloned Kv channels nor endogenous Na(+) and Ca(2+) channels (L- and T-type) in guinea pig cardiac myocytes.
NS11021 displayed better specificity and a 10 times higher potency compared with the most broadly applied KCa1.1 opener, NS1619.
NS11021 leads to relaxation of both intracavernous arteries and corpus cavernosum strips primarily through opening of BK(Ca) channels.

物理化学性质&存储条件

分子量 511.2
分子式 C16H9BrF6N6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea

参考文献

1. Bentzen BH, et al. Mol Pharmacol. 2007 Oct;72(4):1033-44.

2. Kun A, et al. Br J Pharmacol. 2009 Nov;158(6):1465-76.

3. Layne JJ, et al. Am J Physiol Regul Integr Comp Physiol. 2010 Feb;298(2):R378-84.

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