NS-5806 |CAS:426834-69-7 Probechem Biochemicals

Chemical Structure : NS-5806

CAS No.: 426834-69-7

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NS-5806 (NS5806 )

货号: PC-61462Not For Human Use, Lab Use Only.

NS-5806 (NS5806) is a potent Kv4.3 channel activator that mediates the transient outward K+ current (Ito).

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3680	In stock
50 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

NS-5806 (NS5806) is a potent Kv4.3 channel activator that mediates the transient outward K+ current (Ito).
NS-5806 increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 with EC50 of 5.3 uM.
NS-5806 also decays Kv4.1 independent of KChIP2, strongly inhibits Kv1.4 at 10 uM, but has no effect on Kv7.1, Kv11.1 and K(ir)2 currents.
NS-5806 increases ventricular Ito with a leftward shift in Ito activation and accelerated restitution at 10 uM.

物理化学性质&存储条件

分子量	574.07
分子式	C16H8Br2F6N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea

参考文献

1. Calloe K, et al. Cardiovasc Res. 2009 Mar 1;81(4):686-94.

2. Gonzalez WG, et al. J Biol Chem. 2014 Nov 14;289(46):32201-13.

3. Lundby A, et al. Br J Pharmacol. 2010 Aug;160(8):2028-44.

4. Cheng H, et al. Physiol Rep. 2017 Mar;5(5). pii: e13172.

NS-5806 (NS5806 )

生物&药学活性

物理化学性质&存储条件

参考文献

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NS-5806 (NS5806 )

生物&药学活性

物理化学性质&存储条件

参考文献

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