NS-3-008 |CAS:1172854-54-4 Probechem Biochemicals

Chemical Structure : NS-3-008

CAS No.: 1172854-54-4

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NS-3-008 (G0/G1 switch 2 inhibitor)

货号: PC-61825Not For Human Use, Lab Use Only.

NS-3-008 is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

NS-3-008 is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM.
NS-3-008 decreases levels of G0s2 and Ccl2 mRNA in the kidneys (5 mg/kg, p.o.).
NS-3-008 decreases the phosphorylation of Stat5 and p65 protein and suppresses renal inflammation in 5/6Nx mice, ameliorates renal dysfunction in mouse model of chronic kidney disease (CKD).

物理化学性质&存储条件

分子量	269.817
分子式	C14H24ClN3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-benzyl-3-hexylguanidine hydrochloride

参考文献

1. Matsunaga N, et al. EBioMedicine. 2016 Nov;13:262-273.

NS-3-008 (G0/G1 switch 2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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NS-3-008 (G0/G1 switch 2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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