NS-1619 |CAS:153587-01-0 Probechem Biochemicals

Chemical Structure : NS-1619

CAS No.: 153587-01-0

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NS-1619 (NS1619)

货号: PC-43063Not For Human Use, Lab Use Only.

NS-1619 (NS1619) is a selective large-conductance Ca(2+)-dependent K+ channel (BKCa channel) activator with EC50 of 3.6 uM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

NS-1619 (NS1619) is a selective large-conductance Ca(2+)-dependent K+ channel (BKCa channel) activator with EC50 of 3.6 uM.
NS-1619 activates the large-conductance Ca(2+)-dependent K+ channel (BKCa) in membrane patches isolated from rat ventromedial hypothalamic neurones at <30 uM, does not activate ATP-K+ channels.
NS-1619 concentration-dependently inhibits spontaneous activity in rat portal vein at 3-100 uM, activates the large conductance, Ca2+-sensitive channel, BKca and over the same concentration range it inhibits both KV and L-type Ca-channels.

物理化学性质&存储条件

分子量	362.2267
分子式	C15H8F6N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	2H-Benzimidazol-2-one, 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-

参考文献

1. Sellers AJ, et al. Br J Pharmacol. 1994 Nov;113(3):659-61.

2. Olesen SP, et al. Eur J Pharmacol. 1994 Jan 4;251(1):53-9.

3. Edwards G, et al. Br J Pharmacol. 1994 Dec;113(4):1538-47.

4. Lee K, et al. Eur J Pharmacol. 1995 Jul 4;280(2):215-9.

NS-1619 (NS1619)

生物&药学活性

物理化学性质&存储条件

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NS-1619 (NS1619)

生物&药学活性

物理化学性质&存储条件

参考文献

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