NS-062 | EGFR C797S inhibitor | Probechem Biochemicals

Chemical Structure : NS-062

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NS-062 (NS062, NS 062)

货号: PC-35996Not For Human Use, Lab Use Only.

NS-062 (NS062) is a novel, specific targeted covalent inhibitor that shows high reactivity toward Cys797 of EGFR.

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生物&药学活性

NS-062 (NS062) is a novel, specific targeted covalent inhibitor that shows high reactivity toward Cys797 of EGFR.
NS-062 showed higher target specificity for EGFR than the corresponding Michael acceptors in a wide concentration range (0.1-10 μM).
NS-062 showed strong antiproliferative activity (IC50=0.19 μM) against erlotinib-resistant H1975 cells (L858R T790M doublemutant EGFR).
NS-062 effectively inhibited EGFR (Y1068) autophosphorylation in H1975 cells at 0.5 uM, significantly suppressed tumor growth in a mouse xenograft model after oral administration.

物理化学性质&存储条件

分子量	623.483
分子式	C28H30Cl2F2N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-1-(2-chloro-2-fluoroacetyl)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)pyrrolidine-2-carboxamide

参考文献

1. Shindo N, et al. Nat Chem Biol. 2019 Jan 14. doi: 10.1038/s41589-018-0204-3.

NS-062 (NS062, NS 062)

生物&药学活性

物理化学性质&存储条件

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NS-062 (NS062, NS 062)

生物&药学活性

物理化学性质&存储条件

参考文献

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