NS-018 maleate | JAK2 inhibitor | Probechem Biochemicals

Chemical Structure : NS-018 maleate

CAS No.: 1354799-87-3

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NS-018 maleate (NS018 maleate, Ilginatinib maleate)

货号: PC-45662Not For Human Use, Lab Use Only.

NS-018 maleate (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM).

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5 mg	￥2180	In stock
10 mg	￥3480	In stock
25 mg	￥5580	In stock
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100 mg		Get quote

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生物&药学活性

NS-018 maleate (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM).
NS-018 displays 30-50-fold greater selectivity for JAK2 over JAK1, JAK3 and Tyk2.
NS-018 also inhibits Src family kinases(Src, Fyn).
NS-018 shows effective in mouse Ba/F3-JAK2V617F disease model.

物理化学性质&存储条件

分子量	505.501
分子式	C25H24FN7O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	2,6-Pyridinediamine, N2-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-2-pyrazinyl-, (2Z)-2-butenedioate (1:1)

参考文献

1. Nakaya Y, et al. Blood Cancer J. 2011 Jul;1(7):e29.

2. Nakaya Y, et al. Blood Cancer J. 2014 Jan 10;4:e174.

3. Kuroda J, et al. Leuk Res. 2014 May;38(5):619-24.

NS-018 maleate (NS018 maleate, Ilginatinib maleate)

生物&药学活性

物理化学性质&存储条件

参考文献

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NS-018 maleate (NS018 maleate, Ilginatinib maleate)

生物&药学活性

物理化学性质&存储条件

参考文献

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