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首页-小分子抑制剂&激动剂-Epigenetics-Sirtuin -NRD167
NRD167

Chemical Structure : NRD167

CAS No.: 2166487-23-4

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NRD167 (NRD-167, NRD 167)

货号: PC-72768Not For Human Use, Lab Use Only.

NRD167 is a potent and selective, cell-permeant SIRT5 inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NRD167 is a potent and selective, cell-permeant SIRT5 inhibitor.
    NRD167 selectively inhibits cell proliferation and induces apoptosis in SIRT5-dependent cells (OCI-AML2 and SKM-1, IC50=5-8 uM), with minimal effects on SIRT5-independent cells (KG1a and Marimo).
    NRD167 recapitulates SIRT5 KD effects on AML cells.

    物理化学性质&存储条件

    分子量 666.838
    分子式 C34H46N6O6S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ethyl (5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate

    参考文献

    1. Yan D, et al. Blood Cancer Discov. 2021 May;2(3):266-287.

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