NRAS-G4 inhibitor 18

Chemical Structure : NRAS-G4 inhibitor 18

加入收藏

货号: PC-20884Not For Human Use, Lab Use Only.

NRAS-G4 inhibitor 18 is a specific small molecule inhibitor targeting G4 in the 5′-UTR of the NRAS mRNA, binds to a G4 in the NRAS mRNA with KD value of 0.25 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NRAS-G4 inhibitor 18 is a specific small molecule inhibitor targeting G4 in the 5′-UTR of the NRAS mRNA, binds to a G4 in the NRAS mRNA with KD value of 0.25 uM.
NRAS-G4 inhibitor 18 exhibits weak binding toward the RNA-G4 structure formed by AKTIP and DNA-G4 from BCL2, and no significant quenching for other G4s.
NRAS-G4 inhibitor 18 inhibits the translation of NRAS in vitro but showed only moderate effects on the NRAS levels in cellulo.

物理化学性质&存储条件

分子量	486.55
分子式	C25H22N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=S(C1=CC=C(CCNC2=C3C=CC=CC3=NC(C4=NN=C(C5=CC=C(C)C=C5)O4)=N2)C=C1)(N)=O

参考文献

1. Balaratnam S, et al. Cell Chem Biol. 2023 May 26:S2451-9456(23)00140-X.