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NR5A2 inhibitor Cmp3d2

Chemical Structure : NR5A2 inhibitor Cmp3d2

CAS No.: 1185486-16-1

NR5A2 inhibitor Cmp3d2

货号: PC-21459Not For Human Use, Lab Use Only.

NR5A2 inhibitor Cmp3d2 is a specific small molecule inhibitor of NR5A2 (liver receptor homolog-1, LRH-1) with Kd of 1.8 uM in Biacore-based assays, inhibits the transcriptional activity of hLRH-1 with IC50 of 6 uM (G0S2 mRNA level).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NR5A2 inhibitor Cmp3d2 is a specific small molecule inhibitor of NR5A2 (liver receptor homolog-1, LRH-1) with Kd of 1.8 uM in Biacore-based assays, inhibits the transcriptional activity of hLRH-1 with IC50 of 6 uM (G0S2 mRNA level).
NR5A2 inhibitor Cmp3d2 reduces tumor necrosis factor (TNF) production and associated decreased liver damage in a macrophage- and TNF-dependent mouse model of hepatitis.

物理化学性质&存储条件

分子量 364.50
分子式 C21H28N6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(3-{1-[2-(dimethylamino)ethyl]-1H-pyrazol-3-yl}phenyl)-N,N-5,6-tetramethyl-2-pyrimidinamine

参考文献

1. Cindy Benod, et al. J Biol Chem. 2013 Jul 5;288(27):19830-44.

2. Juliane Schwaderer, et al. Cell Death Dis. 2020 Feb 28;11(2):154.

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