NR2F1 agonist C26 |CAS 374101-64-1 Probechem Biochemicals

Chemical Structure : NR2F1 agonist C26

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NR2F1 agonist C26

货号: PC-38249Not For Human Use, Lab Use Only.

NR2F1 agonist C26 is a specific agonist of nuclear receptor NR2F1, significantly induces luciferase expression by 1.7- and 1.9-fold at 0.5 and 1 uM in RARE-luciferase bioassays.

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5 mg		Get quote
10 mg		Get quote
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

NR2F1 agonist C26 is a specific agonist of nuclear receptor NR2F1, significantly induces luciferase expression by 1.7- and 1.9-fold at 0.5 and 1 uM in RARE-luciferase bioassays.
NR2F1 agonist C26 does not bind and activate RXRα.
NR2F1 agonist C26 up-regulates NR2F1 and downstream target genes that regulate dormancy, mRNA levels of SOX9, RARβ, and p27 are all significantly upregulated in C26-treated tumors compared with control.
NR2F1 agonist C26 induces transcriptional changes associated with inhibition of cell cycle progression and mTOR signaling, metastasis suppression, and induction of a neural crest lineage program, and inhibits lung HNSCC metastasis in mice.

物理化学性质&存储条件

分子量	470.635
分子式	C28H30N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(ethylthio)-4-phenethyl-4H-spiro[benzo[h][1,2,4]triazolo[4,3-a]quinazoline-6,1'-cyclohexan]-5(7H)-one

参考文献

1. Bassem D Khalil, et al. J Exp Med. 2022 Jan 3;219(1):e20210836.