NR-160 | HDAC6 inhibitor | Probechem Biochemicals

Chemical Structure : NR-160

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NR-160 (NR160)

货号: PC-72091Not For Human Use, Lab Use Only.

NR-160 (NR160) is a novel potent, selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 30 nM, shows SI (75-1847 )over all HDAC class I isoforms.

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生物&药学活性

NR-160 (NR160) is a potent, selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 30 nM, shows SI (75-1847 )over all HDAC class I isoforms.
NR-160 induced α-tubulin acetylation (ac-α-tubulin) in treated acute myeloid leukemic (AML) cell line HL60, but not histone H3 (ac-H3) (a marker for the inhibition of class I HDACs).
NR-160 enhances the cytotoxicity induction of bortezomib, epirubicin and daunorubicin on a panel of seven leukemia cell lines

物理化学性质&存储条件

分子量	510.477
分子式	C25H21F3N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1-benzyl-1H-tetrazol-5-yl)methyl)-N-(4-(hydroxycarbamoyl)benzyl)-2-(trifluoromethyl)benzamide

参考文献

1. Nina Reßing, et al. J Med Chem. 2020 Sep 24;63(18):10339-10351.

NR-160 (NR160)

生物&药学活性

物理化学性质&存储条件

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NR-160 (NR160)

生物&药学活性

物理化学性质&存储条件

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