NPY5RA-972 | NPY5R antagonist | Probechem Biochemicals

Chemical Structure : NPY5RA-972

CAS No.: 439861-56-0

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NPY5RA-972 (NPY5R antagonist)

货号: PC-38604Not For Human Use, Lab Use Only.

NPY5RA-972 is a potent, highly selective, orally active, and CNS-penetrant neuropeptide Y5 receptor (NPY5) antagonist with IC50 of 3.1 nM, highly selective with respect to Y1, Y2, and Y4 receptors.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
100 mg		Get quote

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生物&药学活性

NPY5RA-972 is a potent, highly selective, orally active, and CNS-penetrant neuropeptide Y5 receptor (NPY5) antagonist with IC50 of 3.1 nM, highly selective with respect to Y1, Y2, and Y4 receptors.
NPY5RA-972 is a highly potent Y5 antagonist in vivo, but chronic administration of NPY5RA-972 (10 mg/kg twice daily) had no effect on food intake or body weight in either free-feeding Wistar rats or dietary obese rats..

物理化学性质&存储条件

分子量	351.44
分子式	C21H25N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-Methyl-9-(1-methylethyl)-9H-carbazol-3-yl]-4-morpholinecarboxamide

参考文献

1. Michael H Block, et al. J Med Chem. 2002 Aug 1;45(16):3509-23.

2. Turnbull AV, et al. Diabetes. 2002 Aug;51(8):2441-9.

NPY5RA-972 (NPY5R antagonist)

生物&药学活性

物理化学性质&存储条件

参考文献

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NPY5RA-972 (NPY5R antagonist)

生物&药学活性

物理化学性质&存储条件

参考文献

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