NPSR1 antagonist Compound 6

Chemical Structure : NPSR1 antagonist Compound 6

加入收藏

货号: PC-28044Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NPSR1 antagonist Compound 6 is a potent, selective and peripherally biased neuropeptide S receptor 1 (NPSR1, GPR154) with IC50 of 0.35 nM and 0.15 nM in calcium assay against NPSR1-A and NPSR1-B, respectively.
NPSR1 antagonist Compound 6 has IC50 of 0.22 nM in the cAMP assay.
NPSR1 antagonist Compound 6 effectively inhibits the expression of the NPS-induced markers without affecting expression of non-NPS induced genes in NPSR1-A expressing fibroblasts.
NPSR1 antagonist Compound 6 (10 mg/kg) reduces TNF-α and altered macrophage populations in zymosan-induced inflammatory mouse model.

物理化学性质&存储条件

分子量	528.69
分子式	C30H42F2N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((4,4-difluoro-1-(4-methylpiperazin-1-yl)cyclohexyl)methyl)-N-((1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)cyclohexanecarboxamide

参考文献

1. Berger KJ, et al. Bioorg Med Chem Lett. 2025 Dec 1;128:130353.