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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-CMV-NPP-669
NPP-669

Chemical Structure : NPP-669

CAS No.: 2407828-99-1

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NPP-669 (NPP669)

货号: PC-49840Not For Human Use, Lab Use Only.

NPP-669 (NPP669) is an orally bioavailable cidofovir (CDV) analogue and prodrug, has increased lipophilicity, improved oral absorption, reduced nephrotoxicity, increased cellular uptake, and increased activity against several dsDNA viruses compared to CDV.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NPP-669 (NPP669) is an orally bioavailable cidofovir (CDV) analogue and prodrug, has increased lipophilicity, improved oral absorption, reduced nephrotoxicity, increased cellular uptake, and increased activity against several dsDNA viruses compared to CDV.
    NPP-669 exhibits two to three orders of magnitude improved antiviral activity compared to cidofovir (CDV, Vistide).
    NPP-669 is more efficacious than antiviral compounds currently in clinical use against adenovirus (AdV-5), herpesviruses (HSV-1 and HSV-2, HCMV, VZV, EBV, HHV-6, and HHV-8) and polyomaviruses (JC and BK virus), while it is on par with BCV.
    NPP-669 has a metabolic half-life of 202 min in rat hepatocytes, which was significantly improved compared to BCV.
    NPP-669 is also significantly more potent than the parent drug CDV against HCMV.
    NPP-669 (0.1 mg/kg) inhibits the replication of HAdV-C6 in the liver of immunosuppressed Syrian hamsters and prevents the resulting pathology.

    物理化学性质&存储条件

    分子量 638.80
    分子式 C28H52N3O8PS.H3N
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((13-cyclobutyltridecyl)sulfonyl)propyl (S)-(((1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate

    参考文献

    1. Lipka E, et al. Mol Pharm. 2023 Jan 2;20(1):370-382.

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