NPD926 | ROS inducer | Probechem Biochemicals

Chemical Structure : NPD926

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NPD926 (NPD-926, NPD 926)

货号: PC-61519Not For Human Use, Lab Use Only.

NPD926 is a small molecule ROS inducer that induces rapid cell death in cancer cells, induces reactive oxygen species via cellular glutathione depletion.

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生物&药学活性

NPD926 is a small molecule ROS inducer that induces rapid cell death in cancer cells, induces reactive oxygen species via cellular glutathione depletion.
NPD926 preferentially induces effects in KRAS-transformed fibroblast cells, compared with their untransformed counterparts, sensitizes cells to inhibitors of system x(c)⁻, a cystine-glutamate antiporter considered to be a potential therapeutic target in cancers including cancer stem cells.

物理化学性质&存储条件

分子量	479.061
分子式	C29H35ClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(4-(dimethylamino)benzyl)-N-(3-(4-isopropoxyphenyl)-3-phenylpropyl)acetamide

参考文献

1. Kawamura T, et al. Biochem J. 2014 Oct 1;463(1):53-63.

NPD926 (NPD-926, NPD 926)

生物&药学活性

物理化学性质&存储条件

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NPD926 (NPD-926, NPD 926)

生物&药学活性

物理化学性质&存储条件

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