NPD13668 |CAS:864819-54-5 Probechem Biochemicals

Chemical Structure : NPD13668

加入收藏

NPD13668 (NPD-13668;NPD 13668)

货号: PC-36041Not For Human Use, Lab Use Only.

NPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels.
NPD13668 reactivates the expression of silenced H3K27me3 target genes together with depletion of the H3K27me3 modification.
NPD13668 effectively suppressed the cell growth of solid tumors even without EZH2 active mutations.
NPD13668 inhibits cell proliferation in many cancer cells (PC3 cell IC50=5.39 uM).
NPD13668 is a potential modulator of EZH2 methyltransferase activity.

物理化学性质&存储条件

分子量	392.411
分子式	C22H20N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(1H-indol-3-yl)ethyl)-2-(7,8-dihydroxy-4-methyl-2-oxo-2H-chromen-3-yl)acetamide

参考文献

1. Murashima A, et al. J Biochem. 2019 Jan 25. doi: 10.1093/jb/mvz007.

NPD13668 (NPD-13668;NPD 13668)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NPD13668 (NPD-13668;NPD 13668)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.