NPAS3 inhibitor 6

Chemical Structure : NPAS3 inhibitor 6

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货号: PC-21007Not For Human Use, Lab Use Only.

NPAS3 inhibitor 6 is a highly potent neuronal PAS domain protein 3 (NPAS3) inhibitor with IC50 of 282 nM, blocks the NPAS3-ARNT heterodimerization by covalently conjugating ARNT Cys336 residue.

规格	价格	库存	数量
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1 g		Get quote

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生物&药学活性

NPAS3 inhibitor 6 is a highly potent neuronal PAS domain protein 3 (NPAS3) inhibitor with IC50 of 282 nM, blocks the NPAS3-ARNT heterodimerization by covalently conjugating ARNT Cys336 residue.
NPAS3 inhibitor 6 effectively down-regulated NPAS3's transcriptional function by disrupting the interface of NPAS3-ARNT complexes at cellular level.
Neuronal PAS domain protein 3 (NPAS3), a basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) family member, is a pivotal transcription factor in neuronal regeneration, development, and related diseases, regulating the expression of downstream genes.

物理化学性质&存储条件

分子量	295.35
分子式	C10H5N3O2S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=[N+](C1=CN=C(SC2=NC3=CC=CC=C3S2)S1)[O-]

参考文献

1. Li P, et al. Bioorg Chem. 2023 Jun 10;139:106676.