NP627 | PKCδI inhibitor | Probechem Biochemicals

Chemical Structure : NP627

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NP627 (NP-627, NP 627)

货号: PC-73059Not For Human Use, Lab Use Only.

NP627 (NP-627) is a specific small-molecule inhibitor of protein kinase C deltaI (PKCδI) with Kd of 1 nM.

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生物&药学活性

NP627 (NP-627) is a specific small-molecule inhibitor of protein kinase C deltaI (PKCδI) with Kd of 1 nM.
NP627 inhibits the cleavage of PKCδI in adipocyte (at 10 nM) and decreases PKCδI kinase activity.
NP627 does not inhibit other PKC isozyme activities.
NP627 prevents caspase-3 mediated cleavage of PKCδI, significantly inhibits PKCδI catalytic fragment release, decreases inflammation and apoptosis, and significantly improves mitochondrial metabolism in human adipocytes from obese individuals.

物理化学性质&存储条件

分子量	560.571
分子式	C27H28N8O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N'1,N'5-bis(3-(1,3-dioxoisoindolin-2-yl)-1-iminopropyl)glutarohydrazide

参考文献

1. Sparks RP, et al. J Biol Chem. 2019 Oct 11;294(41):14896-14910.

NP627 (NP-627, NP 627)

生物&药学活性

物理化学性质&存储条件

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NP627 (NP-627, NP 627)

生物&药学活性

物理化学性质&存储条件

参考文献

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