NP10679 | GluN2B inhibitor | Probechem Biochemicals

Chemical Structure : NP10679

CAS No.: 2914889-88-4

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NP10679 (NP 10679)

货号: PC-72104Not For Human Use, Lab Use Only.

NP10679 (NP 10679) is a potent, orally active, NMDA receptor subunit 2B (GluN2B)-selective inhibitor of NMDA receptor with IC50 of 23 nM, with no significant effect on GluN2A/C/D (IC50>100 uM).

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

NP10679 (NP 10679) is a potent, orally active, NMDA receptor subunit 2B (GluN2B)-selective inhibitor of NMDA receptor with IC50 of 23 nM, with no significant effect on GluN2A/C/D (IC50>100 uM).
NP10679 demonstrates high pH sensitivity, NP10679 exhibits both a potent IC50 at pH 6.9 of 23 nM with a ratio of IC50 at pH 7.6 to that at pH 6.9 (referred to as pH Boost) of 6.2 fold.
NP10679 reduced infarct volume n a dose-dependent manner with an ED50 of 1 mg/kg IP dose and a maximum infarct volume reduction of 52% in MCAo experiments.
NP10679 perturbed motor coordination or function in mice.

物理化学性质&存储条件

分子量	449.474
分子式	C23H26F3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (4.5 mg/mL)
Chemical Name/SMILES	(R)-6-(2-Hydroxy-3-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propoxy)-3,4-dihydroquinolin-2(1H)-one

参考文献

1. Scott J Myers, et al. J Pharmacol Exp Ther. 2021 Oct;379(1):41-52.

NP10679 (NP 10679)

生物&药学活性

物理化学性质&存储条件

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NP10679 (NP 10679)

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