NP-C86 | GAS5 modulator | Probechem Biochemicals

Chemical Structure : NP-C86

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NP-C86 (GAS5 modulator NP-C86)

货号: PC-49043Not For Human Use, Lab Use Only.

NP-C86 is a small molecule that limits the degradation of GAS5 by blocking the interaction of long noncoding RNA (lncRNA) GAS5 and UPF1. NP-C86 binds to GAS5 with high affinity (Kd=153 nM) and stabilize GAS5 levels in vivo.

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生物&药学活性

NP-C86 is a small molecule that limits the degradation of GAS5 by blocking the interaction of long noncoding RNA (lncRNA) GAS5 and UPF1. NP-C86 binds to GAS5 with high affinity (Kd=153 nM) and stabilize GAS5 levels in vivo.
NP-C86 (20 nM, 24 hours) dramatically reduces (4-fold) the association between UPF1 and GAS5, increases GAS5 levels and glucose uptake in diabetes mellitus (DM) adipocytes.
NP-C86 is specific for lncRNA GAS5, does not affect levels of MALAT1 or NEAT1, the other lncRNAs present in the adipocytes.
NP-C86 restores insulin-mediated glucose uptake in DM adipocytes.

物理化学性质&存储条件

分子量	1225.605
分子式	C68H92N10O9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Yan Shi, et al. Cell Chem Biol. 2019 Mar 21;26(3):319-330.e6.

NP-C86 (GAS5 modulator NP-C86)

生物&药学活性

物理化学性质&存储条件

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NP-C86 (GAS5 modulator NP-C86)

生物&药学活性

物理化学性质&存储条件

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