NP-1815-PX sodium | P2X4 antagonist | Probechem Biochemicals

Chemical Structure : NP-1815-PX sodium

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NP-1815-PX sodium (P2X4 antagonist)

货号: PC-22526Not For Human Use, Lab Use Only.

NP-1815-PX sodium is a potent, selective P2X4 receptor (P2X4R) antagonist, inhibits P2X4R-mediated [Ca2+]i increase in hP2X4R-1321N1 cells with IC50 of 0.26 μM.

规格	价格	库存	数量
10 mg		Get quote
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NP-1815-PX sodium is a potent, selective P2X4 receptor (P2X4R) antagonist, inhibits P2X4R-mediated [Ca2+]i increase in hP2X4R-1321N1 cells with IC50 of 0.26 μM.
NP-1815-PX has no effect on ATP-induced [Ca2+]i increase in hP2X7R- and rP2X3R-1321N1 cells, with IC50 of >30 μM for hP2X1R, rat (r) P2X3R, hP2X2/3R and hP2X7R, and 7.3 μM for hP2X2R.
NP-1815-PX inhibits ATP-mediated responses in primary cultured microglial cells.
NP-1815-PX (10 and 30 pmol/mouse) exhibits an inhibitory effect on mechanical allodynia in a model of herpetic pain.

物理化学性质&存储条件

分子量	425.42
分子式	C21H14N4NaO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3-(5-thioxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl)-1,5-dihydro-2H-naphtho[1,2-b][1,4]diazepine-2,4(3H)-dione, sodium salt

参考文献

1. Matsumura Y, et al. Sci Rep. 2016 Aug 31;6:32461.