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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-NADPH Oxidase (NOX)-NOXA1ds
NOXA1ds

Chemical Structure : NOXA1ds

CAS No.: 1435893-78-9

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NOXA1ds

货号: PC-24326Not For Human Use, Lab Use Only.

NoxA1ds is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor with IC50 of 20 nM, potently inhibits Nox1-derived superoxide anion (O2·-) production with no effect on Nox2-, Nox4-, Nox5-, or xanthine oxidase-derived reactive oxygen species production.

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10 mg ￥3580 In stock
25 mg ￥5880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NoxA1ds is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor with IC50 of 20 nM, potently inhibits Nox1-derived superoxide anion (O2·-) production with no effect on Nox2-, Nox4-, Nox5-, or xanthine oxidase-derived reactive oxygen species production.

物理化学性质&存储条件

分子量 1125.32
分子式 C50H88N14O15
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,6S,9S,12S,18S,21S,24S)-24-((S)-2-((S)-1-(L-glutamyl)pyrrolidine-2-carboxamido)-3-methylbutanamido)-6,12-bis(4-aminobutyl)-3-carbamoyl-18-isobutyl-2,9,21-trimethyl-5,8,11,14,17,20,23-heptaoxo-4,7,10,13,16,19,22-heptaazahexacosan-26-oic acid

参考文献

1. Ranayhossaini DJ, et al. J Biol Chem. 2013 Dec 20;288(51):36437-50.

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