NOS31 | Nox1 inhibitor | Probechem Biochemicals

Chemical Structure : NOS31

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NOS31 (Nox1 inhibitor NOS31)

货号: PC-73003Not For Human Use, Lab Use Only.

NOS31 is a potent, selective NADPH oxidase 1 (Nox1) inhibitor with IC50 of 2.0 uM.

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生物&药学活性

NOS31 is a potent, selective NADPH oxidase 1 (Nox1) inhibitor with IC50 of 2.0 uM.
NOS31 inhibited ROS production in CaCO2 cells in a dose-dependent manner, inhibits NOXO1/NOXA1-induced ROS production.
NOS31 is much less potent with other Nox enzymes Nox2, Nox3, Nox4, and Nox5 in HEK293 reconstitution systems (>15-fold selectivity).
NOS31 inhibited the proliferation of several colon cancer cell lines in vitro (CaCO2, HT-29, DLD-1, RKO, and HCT-116), with no direct antioxidant activity nor cytotoxity.

物理化学性质&存储条件

分子量	472.541
分子式	C28H28N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-hydroxy-3-(2-(2-(4-hydroxyphenyl)-6-methoxy-2,3-dihydrobenzofuran-3-yl)-1H-indol-3-yl)propan-2-yl)acetamide

参考文献

1. Yamamoto T, et al. Biol Pharm Bull. 2018 Mar 1;41(3):419-426.

NOS31 (Nox1 inhibitor NOS31)

生物&药学活性

物理化学性质&存储条件

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NOS31 (Nox1 inhibitor NOS31)

生物&药学活性

物理化学性质&存储条件

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