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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-NOFD
NOFD

Chemical Structure : NOFD

CAS No.: 856680-67-6

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NOFD (N-oxalyl-d-phenylalanine)

货号: PC-60851Not For Human Use, Lab Use Only.

NOFD (N-oxalyl-d-phenylalanine) is a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NOFD (N-oxalyl-d-phenylalanine) is a specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM).
    NOFD also shows lack of in vitro inhibitory activities against a panel of Jumonji-C containing proteins KDM3A, KDM4E, and KDM6B (IC50>20 uM).

    物理化学性质&存储条件

    分子量 237.211
    分子式 C11H11NO5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-oxalyl-d-phenylalanine

    参考文献

    1. McDonough MA, et al. J Am Chem Soc. 2005 Jun 1;127(21):7680-1.

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