NNC 55-0396 |CAS:357400-13-6 Probechem Biochemicals

Chemical Structure : NNC 55-0396

CAS No.: 357400-13-6

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NNC 55-0396 (NNC 55-0396 dihydrochloride)

货号: PC-45854Not For Human Use, Lab Use Only.

NNC 55-0396 is a potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NNC 55-0396 is a potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM.
NNC 55-0396 has no detectable effect on high-voltage-activated channels in INS-1 cells.
NNC 55-0396 inhibits MCF-7 (ERalpha+) cellular proliferation, inhibits tumor-induced angiogenesis in vitro and in vivo by suppressing HIF-1α stability.
NNC 55-0396 significantly suppresses glioblastoma tumor growth in a xenograft model.
NNC 55-0396 is a small molecule inhibitor of the PEX3-PEX19 interaction, effectively disrupts PEX3-PEX19 interaction at 4 μM.
NNC 55-0396 shows anti-tumoral effect, which is dependent on peroxisomal functions, but not on T-type calcium channels (TTCCs).
NNC 55-0396 shows anti-tumor response with MAPK-targeted therapy in melanoma.

物理化学性质&存储条件

分子量	564.5619
分子式	C30H40Cl2FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO
Chemical Name/SMILES	Cyclopropanecarboxylic acid, (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, hydrochloride (1:2)

参考文献

1. Huang L, et al. J Pharmacol Exp Ther. 2004 Apr;309(1):193-9.

2. Taylor JT, et al. Cancer Lett. 2008 Aug 18;267(1):116-24.

3. Kim KH, et al. J Mol Med (Berl). 2015 May;93(5):499-509.

4. Fan Huang, et al. J Clin Invest. 2023 Aug 24;e166644.

NNC 55-0396 (NNC 55-0396 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

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NNC 55-0396 (NNC 55-0396 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

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