NN-429 | HDAC6 inhibitor | Probechem Biochemicals

Chemical Structure : NN-429

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NN-429 (NN429)

货号: PC-49452Not For Human Use, Lab Use Only.

NN-429 (NN429) is a potent, selective second-generation inhibitor of HDAC6 with IC50 of 3.2 nM, >312-fold selectivityt over all HDAC isoforms.

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生物&药学活性

NN-429 (NN429) is a potent, selective second-generation inhibitor of HDAC6 with IC50 of 3.2 nM, >312-fold selectivityt over all HDAC isoforms.
NN-429 is an improved analog of older generation HDAC6 inhibitor molecules KT-531 and NN-390, with higher in vitro selectivity, target potency and in vivo half-life.
NN-429 displays IC50 value of 28.8 nM in fluorescence polarization (FP) assays.
NN-429 shows selective cellular cytotoxicity in a spectrum of T-cell lymphoma malignancies.
NN-429 dose-dependently increases the acetylation of α-tubulin in acute myeloid leukemia (AML) cells (MV4-11) at as low as 0.1 uM.
NN-429 exhibits strong synergy with clinical agents cytarabine, doxorubicin, etoposide, and with SNS-032 in in cellular models of γδ T-NHL and NKTCL.

物理化学性质&存储条件

分子量	438.369
分子式	C17H15F5N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-fluoro-N-hydroxy-4-(((2,3,4,5-tetrafluoro-N-isopropylphenyl)sulfonamido)methyl)benzamide

参考文献

1. Harsimran Kaur Garcha, et al. Pharmaceuticals (Basel). 2022 Oct 26;15(11):1321.

NN-429 (NN429)

生物&药学活性

物理化学性质&存储条件

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NN-429 (NN429)

生物&药学活性

物理化学性质&存储条件

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