NMac1 |CAS:1332290-68-2 Probechem Biochemicals

Chemical Structure : NMac1

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NMac1 (Nm23 activator 1)

货号: PC-35500Not For Human Use, Lab Use Only.

NMac1 (Nm23 activator 1) is a small molecule activator of Nm23/NDPK, directly binds to Nm23-H1 and activates NDPK activity of recombinant Nm23-H1 with EC50 of 10.7 uM.

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生物&药学活性

NMac1 (Nm23 activator 1) is a small molecule activator of Nm23/NDPK, directly binds to Nm23-H1 and activates NDPK activity of recombinant Nm23-H1 with EC50 of 10.7 uM.
NMac1 binds to the C-terminal of Nm23-H1 and induces the NDPK activation through its allosteric conformational changes.
NMac1-treated MDA-MB-231 breast cancer cells showed dramatic changes in morphology and actin-cytoskeletal organization following inhibition of Rac1 activation.
NMac1 also suppressed invasion and migration in vitro, and metastasis in vivo, in a breast cancer mouse model.

物理化学性质&存储条件

分子量	380.484
分子式	C24H28O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(±)-trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene

参考文献

1. Lee JJ, et al. Sci Rep. 2018 Jul 19;8(1):10909.

NMac1 (Nm23 activator 1)

生物&药学活性

物理化学性质&存储条件

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NMac1 (Nm23 activator 1)

生物&药学活性

物理化学性质&存储条件

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