NMS-P645 |CAS:1482518-95-5 Probechem Biochemicals

Chemical Structure : NMS-P645

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NMS-P645 (NMS P645)

货号: PC-63141Not For Human Use, Lab Use Only.

NMS-P645 is a potent, selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively.

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生物&药学活性

NMS-P645 is a potent, selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively.
NMS-P645 exhibits excellent selectivity against a large panel of kinases.
NMS-P645 reverse PIM1-mediated pro-survival signals in prostate cells, such as activation of STAT3 through Tyr705 phosphorylation and resistance to taxane-based treatments.
NMS-P645 induces a significant anti-proliferative response in PCa cells combined with GDC-0941.

物理化学性质&存储条件

分子量	512.095
分子式	C28H38ClN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((S)-7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl)-N-((S)-1-cyclohexyl-2-(4-methylpiperazin-1-yl)ethyl)acetamide

参考文献

1. Casuscelli F, et al. Bioorg Med Chem. 2013 Dec 1;21(23):7364-80.

2. Mologni L, et al. J Cancer. 2017 Jan 1;8(1):140-145.

NMS-P645 (NMS P645)

生物&药学活性

物理化学性质&存储条件

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NMS-P645 (NMS P645)

生物&药学活性

物理化学性质&存储条件

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