欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-p97/VCP-NMS-873
NMS-873

Chemical Structure : NMS-873

CAS No.: 1418013-75-8

加入收藏

NMS-873 (NMS873, VCP Inhibitor III)

货号: PC-38468Not For Human Use, Lab Use Only.

NMS-873 (NMS873) is a potent, specific, cell-permeable, non-ATP competitive, allosteric inhibitor of VCP/p97 ATPase with IC50 of 30 nM.

规格 价格 库存 数量
5 mg ￥680 In stock
10 mg ￥1080 In stock
25 mg ￥1980 In stock
50 mg ￥3480 In stock
100 mg ￥5480 In stock
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NMS-873 (NMS873) is a potent, specific, cell-permeable, non-ATP competitive, allosteric inhibitor of VCP/p97 ATPase with IC50 of 30 nM.
NMS-873 displays high selectivity over all other AAA ATPases, HSP90 and kinases tested at 10 uM.
NMS-873 activates the unfolded protein response (UPR), interferes with autophagy and induced cancer cell death.
p97 A530T mutant is sufficient to overcome the cytotoxicity of NMS-873 and alleviates p97 composition changes caused by the molecule but not other p97 inhibitors.
NMS-873 also is a potent HCMV antiviral with potential for HCMV infection via host VCP/p97 inhibition.
NMS-873 exhibits antiproliferative activity in cancer cells in vitro (IC50= 400 and 700 nM for HCT116 and HeLa cells respectively).

物理化学性质&存储条件

分子量 520.666
分子式 C27H28N4O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine

参考文献

1. Magnaghi P, et al. Nat Chem Biol. 2013 Sep;9(9):548-56.

2. Daniel J Anderson, et al. Cancer Cell. 2015 Nov 9;28(5):653-665.

3. Her NG, et al. Cell Chem Biol. 2016 Apr 21;23(4):517-28.

4. Lin YT, et al. PLoS Pathog. 2017 May 11;13(5):e1006329.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: