NMD670 sodium | ClC-1 inhibitor | Probechem Biochemicals

Chemical Structure : NMD670 sodium

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NMD670 sodium (NMD-670, NMD 670)

货号: PC-22008Not For Human Use, Lab Use Only.

NMD670 (NMD-670) sodium salt is a potent, specific and orally bioavailable ClC-1 chloride channel inhibitor with EC50 of 1.6 uM, restores muscle function in rat models of myasthenia gravis (MG).

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生物&药学活性

NMD670 (NMD-670) sodium salt is a potent, specific and orally bioavailable ClC-1 chloride channel inhibitor with EC50 of 1.6 uM, restores muscle function in rat models of myasthenia gravis (MG).
NMD670 shows no effect on Gm in a Cl− free experimental solution.
NMD670 (20 mg/kg) enhances neuromuscular transmission and restores muscle function in experimental autoimmune myasthenia gravis (MG) rats.
NMD670 (20 mg/kg) restores muscle force and motor performance in rat models of MG.
NMD670 improves running performance in a passive immunization MG rat model.

物理化学性质&存储条件

分子量	335.11
分子式	C12H10BrNO4.Na
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(4-bromo-2-(isoxazol-3-yl)phenoxy)propanoic acid, sodium salt

参考文献

1. Martin Skov, et al. Sci Transl Med. 2024 Mar 20;16(739):eadk9109.

NMD670 sodium (NMD-670, NMD 670)

生物&药学活性

物理化学性质&存储条件

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NMD670 sodium (NMD-670, NMD 670)

生物&药学活性

物理化学性质&存储条件

参考文献

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