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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Nur77 (NR4A1)-NMA39
NMA39

Chemical Structure : NMA39

CAS No.: 2624191-96-2

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NMA39

货号: PC-26964Not For Human Use, Lab Use Only.

NMA39 is a small-molecule Nur77 modulator (SPR Kd=563 nM) that disrupts the Nur77-Cep192 interaction, induces mitotic arrest and death in tumor cells, also blocks Nur77-PLK1 interaction during mitosis, mimicking the effect of Cdk1 inhibition.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NMA39 is a small-molecule Nur77 modulator (SPR Kd=563 nM) that disrupts the Nur77-Cep192 interaction, induces mitotic arrest and death in tumor cells, also blocks Nur77-PLK1 interaction during mitosis, mimicking the effect of Cdk1 inhibition.

物理化学性质&存储条件

分子量 493.69
分子式 C31H43NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,4aS,6aS,9S,12bR,14aS,14bR)-9-methoxy-N,2,4a,6a,9,12b,14a-heptamethyl-10,11-dioxo-1,2,3,4,4a,5,6,6a,9,10,11,12b,13,14,14a,14b-hexadecahydropicene-2-carboxamide

参考文献

1. Guobin Xie, et al. Cell Death Dis. 2026 Jun 3. doi: 10.1038/s41419-026-08870-3.

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