NKY80 | AC5/6 inhibitor | Probechem Biochemicals

Chemical Structure : NKY80

CAS No.: 299442-43-6

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NKY80 (NKY 80, NKY-80)

货号: PC-60667Not For Human Use, Lab Use Only.

A potent, selective adenylyl cyclase AC5/6 inhibitor with IC50 of 7.7/17 uM, respectively.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg	￥4280	In stock
250 mg		Get quote

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生物&药学活性

NKY80 is a potent, selective adenylyl cyclase AC5/6 inhibitor with IC50 of 7.7/17 uM, respectively.
NKY80 displays little to no activity for other AC isoforms (IC50>100 uM).
NKY80 blocks both BAPTA-AM-stimulated cAMP formation and renin release in primary cultures of juxtaglomerular cells.

物理化学性质&存储条件

分子量	229.239
分子式	C12H11N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone

参考文献

1. Onda T, et al. J Biol Chem. 2001 Dec 21;276(51):47785-93.

2. Ortiz-Capisano MC, et al. Hypertension. 2007 Mar;49(3):618-24.

3. Brand CS, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):265-75.

NKY80 (NKY 80, NKY-80)

生物&药学活性

物理化学性质&存储条件

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NKY80 (NKY 80, NKY-80)

生物&药学活性

物理化学性质&存储条件

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