NKTR-181 |CAS:1211231-76-3 Probechem Biochemicals

Chemical Structure : NKTR-181

加入收藏

NKTR-181 (NKTR 181;NKTR181;Loxicodegol)

货号: PC-60802Not For Human Use, Lab Use Only.

A novel, long-acting and orally active, selective mu-opioid agonist that displays higher binding affinity (Ki=237 nM) at the MOR than kappa and delta opioid receptors (>100-fold).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NKTR-181 (Loxicodegol) is a long-acting and orally active, selective mu-opioid agonist that displays higher binding affinity (Ki=237 nM) at the MOR than kappa and delta opioid receptors (>100-fold);.
NKTR-181 demonstrates maximum analgesic activity comparable to that of oxycodone in hot-plate latency and acetic-acid writhing models.
NKTR-181 reduces its rate of entry across the blood-brain barrier compared with traditional mu-opioid agonists.

物理化学性质&存储条件

分子量	595.73
分子式	C31H49NO10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4R,4aS,7S,7aR,12bS)-7-((2,5,8,11,14,17-hexaoxanonadecan-19-yl)oxy)-9-methoxy-3-methyl-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinolin-4a-ol

参考文献

1. Miyazaki T, et al. J Pharmacol Exp Ther. 2017 Oct;363(1):104-113.

2. Webster L, et al. Pain Med. 2017 Mar 10. doi: 10.1093/pm/pnw344.

NKTR-181 (NKTR 181;NKTR181;Loxicodegol)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NKTR-181 (NKTR 181;NKTR181;Loxicodegol)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.