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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Adenylate Cyclase-NKH477
NKH477

Chemical Structure : NKH477

CAS No.: 138605-00-2

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NKH477 (Colforsin dapropate hydrochloride)

货号: PC-62254Not For Human Use, Lab Use Only.

NKH477 (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase, shows some selectivity for cardiac (type V) adenylyl cyclase.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NKH477 (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase, shows some selectivity for cardiac (type V) adenylyl cyclase.
NKH477 increases cAMP accumulation in HEK293 cells stably overexpressing type V more than forskolin.
NKH477 also is a PKA activator.

物理化学性质&存储条件

分子量 546.1
分子式 C27H43NO8.HCl
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-β-alanine, N,N-dimethyl-oxo-1H-naphtho[2,1-b]pyran-6-yl ester hydrochloride

参考文献

1. Hosono M, et al. J Cardiovasc Pharmacol. 1992 Apr;19(4):625-34.

2. Toya Y, et al. J Mol Cell Cardiol. 1998 Jan;30(1):97-108.

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