NKG2D inhibitor 4e

Chemical Structure : NKG2D inhibitor 4e

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货号: PC-21268Not For Human Use, Lab Use Only.

NKG2D inhibitor 4e is a small-molecule protein-protein interaction inhibitor for NKG2D with IC50 of 2.2 uM, disrupts the interaction between NKG2D and multiple protein ligands through allosteric modulation of the NKG2D receptor dimer/ligand interface.

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1 g		Get quote

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生物&药学活性

NKG2D inhibitor 4e is a small-molecule protein-protein interaction inhibitor for NKG2D with IC50 of 0.1 uM, disrupts the interaction between NKG2D and multiple protein ligands through allosteric modulation of the NKG2D receptor dimer/ligand interface.

物理化学性质&存储条件

分子量	455.48
分子式	C25H24F3N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(2-(dimethylamino)-1-(3,5-dimethylphenyl)-2-oxoethyl)-4-(4-(trifluoromethyl)phenyl)nicotinamide

参考文献

1. Thompson AA, et al. Proc Natl Acad Sci U S A. 2023 May 2;120(18):e2216342120.