NK150460 | AhR agonist | Probechem Biochemicals

Chemical Structure : NK150460

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NK150460 (NK 150460;NK-150460)

货号: PC-60775Not For Human Use, Lab Use Only.

NK150460 is a potent and selective inhibitor of breast cancer cells via activation the aryl hydrocarbon receptor (AhR) pathway.

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生物&药学活性

NK150460 is a potent and selective inhibitor of breast cancer cells via activation the aryl hydrocarbon receptor (AhR) pathway.
NK150460 inhibits growth of not only most ER-positive, but also some ER-negative breast cancer cell lines, while never inhibiting growth of non-breast cancer cell lines.
NK150460 inhibits 17β-estradiol (E2)-dependent transcription without affecting binding of E2 to ER.
NK150460 does not induce histone H2AX phosphorylation or p53 expression.
NK150460 is a a novel AhR agonist dependent on AhR/ARNT and cytochrome P450 CYP1A1.

物理化学性质&存储条件

分子量	308.304
分子式	C16H15F3N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5S,7S)-7-methyl-3-(3-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrocinnolin-5-ol

参考文献

1. Fukasawa K, et al. Mol Cancer Ther. 2015 Feb;14(2):343-54.

2. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827.

NK150460 (NK 150460;NK-150460)

生物&药学活性

物理化学性质&存储条件

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NK150460 (NK 150460;NK-150460)

生物&药学活性

物理化学性质&存储条件

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