NK1-IN-9 |CAS:1100211-97-9 Probechem Biochemicals

首页-小分子抑制剂&激动剂-GPCR-Neurokinin Receptor-NK1-IN-9

Chemical Structure : NK1-IN-9

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NK1-IN-9 (NK1/SERT inhibitor)

货号: PC-60173Not For Human Use, Lab Use Only.

NK1-IN-9 is a potent, orally active, dual NK1 receptor antagonist (IC50=0.5 nM) and SERT inhibitor (IC50=5.2 nM).

规格	价格	库存	数量
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100 mg		Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NK1-IN-9 is a potent, orally active, dual NK1 receptor antagonist (IC50=0.5 nM) and SERT inhibitor (IC50=5.2 nM).
NK1-IN-9 demonstrates favorable oral bioavailability, excellent brain uptake, and robust in vivo efficacy in a validated depression model.

物理化学性质&存储条件

分子量	436.352
分子式	C22H24Cl2FN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3,5-dichloro-7-(1-((4-(4-fluorophenyl)-1-methylpiperidin-4-yl)methoxy)ethyl)-1H-indazole

参考文献

1. Degnan AP, et al. ACS Chem Neurosci. 2016 Dec 21;7(12):1635-1640.

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NK1-IN-9 (NK1/SERT inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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NK1-IN-9 (NK1/SERT inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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