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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-NK-252
NK-252

Chemical Structure : NK-252

CAS No.: 1414963-82-8

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NK-252 (NK 252;NK252)

货号: PC-45694Not For Human Use, Lab Use Only.

NK-252 (NK252) is a small molecule Nrf2 activator, exhibits a greater Nrf2-activating potential than oltipraz (OPZ).

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10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NK-252 (NK252) is a small molecule Nrf2 activator, exhibits a greater Nrf2-activating potential than oltipraz (OPZ).
NK-252 interacts with the domain containing the Nrf2-binding site of Keap1.
NK-252 upregulates NQO1 gene expression and exerts antioxidant property in the liver of NASH model rats.

物理化学性质&存储条件

分子量 285.2581
分子式 C13H11N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 29 mg/mL
Chemical Name/SMILES

Urea, N-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)-

参考文献

1. Shimozono R, et al. Mol Pharmacol. 2013 Jul;84(1):62-70.

2. Kiue A, et al. Jpn J Cancer Res. 1990 Oct;81(10):1057-64.

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