NJNU-0069

Chemical Structure : NJNU-0069

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货号: PC-20891Not For Human Use, Lab Use Only.

NJNU-0069 is a specific small-molecule inducer of major histocompatibility complex class II (MHC-II), directly binds to the MAT domain of FASN (Kd=32.1 uM).

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生物&药学活性

NJNU-0069 is a specific small-molecule inducer of major histocompatibility complex class II (MHC-II), directly binds to the MAT domain of FASN (Kd=32.1 uM).
NJNU-0069 potently elevated the expression of MHC II genes and upregulated the surface MHC-II protein levels in a dose-dependent manner in cancer cells, including 4T1, MCF-7, and Hs578T.
NJNU-0069 is an analog of pristane, exhibits about 26-fold higher binding affinity to MAT than pristane did (NJNU-0069 Kd: 32.1 μM vs. pristane Kd: 840.6 μM).
NJNU-0069 (100 mg/kg for four times every other day) can effectively inhibit the growth on Balb/c mice bearing 4T1 tumors, fires up the tumor microenvironment by promoting immune detection.

物理化学性质&存储条件

分子量	429.69
分子式	C28H47NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1NC2=C(C=C(OCC(C)CCCC(C)CCCC(C)CCCC(C)C)C=C2)CC1

参考文献

1. Ling Huang, et al. Cell Chem Biol. 2023 May 22;S2451-9456(23)00126-5.

NJNU-0069

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物理化学性质&存储条件

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NJNU-0069

生物&药学活性

物理化学性质&存储条件

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