NJNU-0069-003

Chemical Structure : NJNU-0069-003

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货号: PC-20892Not For Human Use, Lab Use Only.

NJNU-0069-003 is a specific small-molecule inducer of major histocompatibility complex class II (MHC-II), directly binds to the MAT domain of FASN with Kd of 7.98 uM.

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生物&药学活性

NJNU-0069-003 is a specific small-molecule inducer of major histocompatibility complex class II (MHC-II), directly binds to the MAT domain of FASN with Kd of 7.98 uM.
NJNU-0069-003 increases the expression of MHC-II genes, dose-dependently upregulates the surface MHC-II protein levels in 4T1 mouse cancer cells and human cancer cells including MCF-7 and Hs578T.
NJNU-0069-003 cannot upregulate the expression of IFN-γ responsive genes and was unable to activate the JAK/STAT signaling pathway.
NJNU-0069-003 (100 mg/kg for four times every other day) can effectively inhibit the growth on Balb/c mice bearing 4T1 tumors, fires up the tumor microenvironment by promoting immune detection.

物理化学性质&存储条件

分子量	515.78
分子式	C32H53NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 2-(2-oxo-6-((2,6,10,14-tetramethylpentadecyl)oxy)-3,4-dihydroquinolin-1(2H)-yl)acetate

参考文献

1. Ling Huang, et al. Cell Chem Biol. 2023 May 22;S2451-9456(23)00126-5.

NJNU-0069-003

生物&药学活性

物理化学性质&存储条件

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NJNU-0069-003

生物&药学活性

物理化学性质&存储条件

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