NITD008 | Flavivirus inhibitor | Probechem Biochemicals

Chemical Structure : NITD008

CAS No.: 1044589-82-3

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NITD008 (NITD 008)

货号: PC-38666Not For Human Use, Lab Use Only.

NITD008 is a selective, adenosine-based flavivirus inhibitor, inhibits dengue virus (DENV, EC50= 0.64 μM), HCV and cellular entry of ZIKV, also has potent antiviral activity against EV71 with EC50 of 0.67 uM in cell culture.

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10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

NITD008 is a selective, adenosine-based flavivirus inhibitor, inhibits dengue virus (DENV, EC50= 0.64 μM), HCV and cellular entry of ZIKV, also has potent antiviral activity against EV71 with EC50 of 0.67 uM in cell culture.
NITD008 also inhibits other flaviviruses, including West Nile virus, yellow fever virus, and Powassan virus.
NITD008 directly inhibits the RNA-dependent RNA polymerase activity of DENV.
NITD008 suppressed peak viremia, reduced cytokine elevation, and completely prevented the infected mice from death in DENV-infected mice.

物理化学性质&存储条件

分子量	290.279
分子式	C13H14N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3R,4R,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

参考文献

1. Yin Z, et al. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20435-9.

2. Shang L, et al. Antiviral Res. 2014 Dec;112:47-58.

3. Deng CL, et al. J Virol. 2014 Oct;88(20):11915-23.

NITD008 (NITD 008)

生物&药学活性

物理化学性质&存储条件

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NITD008 (NITD 008)

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