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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-NITD-349
NITD-349

Chemical Structure : NITD-349

CAS No.: 1473450-62-2

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NITD-349 (NITD349)

货号: PC-61755Not For Human Use, Lab Use Only.

NITD-349 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 23 nM against M tuberculosis H37Rv.

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5 mg ￥680 In stock
10 mg ￥980 In stock
25 mg ￥1680 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NITD-349 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 23 nM against M tuberculosis H37Rv.
NITD-349 shows potent activity against both drug-sensitive and multidrug-resistant clinical isolates of Mtb.
NITD-349 demonstrates effectivity in treating both acute and chronic Mtb infections in mouse efficacy models.

物理化学性质&存储条件

分子量 306.36
分子式 C17H20F2N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4,4-dimethylcyclohexyl)-4,6-difluoro-1H-indole-2-carboxamide

参考文献

1. Rao SP, et al. Sci Transl Med. 2013 Dec 4;5(214):214ra168.

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