NITD-304 |CAS:1473450-60-0 Probechem Biochemicals

Chemical Structure : NITD-304

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NITD-304 (NITD304)

货号: PC-61756Not For Human Use, Lab Use Only.

NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv.

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生物&药学活性

NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv.
NITD-304 shows potent activity against both drug-sensitive and multidrug-resistant clinical isolates of Mtb.
NITD-304 demonstrates effectivity in treating both acute and chronic Mtb infections in mouse efficacy models.

物理化学性质&存储条件

分子量	339.27
分子式	C17H20Cl2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,6-dichloro-N-(4,4-dimethylcyclohexyl)-1H-indole-2-carboxamide

参考文献

1. Rao SP, et al. Sci Transl Med. 2013 Dec 4;5(214):214ra168.

NITD-304 (NITD304)

生物&药学活性

物理化学性质&存储条件

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NITD-304 (NITD304)

生物&药学活性

物理化学性质&存储条件

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